which of these statements accurately describes an mtoc?

which of these statements accurately describes an mtoc?

which of these statements accurately describes an mtoc?

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Structural and Functional Insights into the Microtubule Organizing Centers of Toxoplasma gondii and Plasmodium spp

Invariably, microtubule organizing centers (MTOCs) perform critical cellular tasks by nucleating, stabilizing, and anchoring microtubule’s (MT) minus ends. These capacities are required for a wide array of functions,
including ascribing cells with their characteristic shape and polarity,
influencing resistance to mechanical forces, organizing the mitotic spindle,
or acting as basal bodies (BBs) positioning and contributing to the nucleation and motility of cilia and flagella,
and in this way, impacting intracellular transport, signaling, and cellular differentiation.
The fascinating biology of MTOCs, and their role in cellular life, health,
and disease has attracted scientists since the late 1800s .
which of these statements accurately describes an mtoc?
which of these statements accurately describes an mtoc?

A remarkable landmark in MTOC research history is Theodore Boveri’s monograph
‘Ueber die Natur der Centrosomen’ written in the 1900s.
His initial observations of mitotically dividing fertilized eggs of the nematode Parascaris equorum
 (then Ascaris megalocephala) established that the formation of mitotic spindles was controlled by a cellular organelle which persisted,
replicated, and was inherited. His coining of the term “centrosome” in 1887  sparked the interest for this structure which has provided,
since, over 120 years of wonderland for microscopists and cell biologists.

Microtubule Organizing Centers of Toxoplasma

In the best studied higher eukaryote systems—such as humans and other animals—the centrosome performs the majority of the MTOC aforementioned functions. Animal centrosomes are characterized by the presence of two MT-based barrels known as centrioles. Centrioles are precisely organized. Centriolar MT organize following a nine-fold radial symmetry determined by.
a foundational structure known as the cartwheel. The cartwheel is a structure formed onto a pre-existing centriole (a “mother” centriole), guided by the self-assembling properties of the Spindle assembly abnormal protein 6 homolog (SAS6).
SAS6 interacts with other proteins, such as SCL-interrupting locus protein (STIL) and CEP135 .
to complete the cartwheel structure defining the geometric arrangement of the nine MT triplets.
These triplets are each made up of a complete MT (A-tubule) and two incomplete tubules (named B and C).
Precisely controlled MT polymerization completes the centriole cylindrical structure. The length of the centriolar MTs growing apically from the cartwheel is tightly regulated and cell-type specific

Is the MTOC the centrosome?

MTOCs can be broadly defined as sites that localize microtubule minus ends, with functions that include microtubule nucleation, stabilization, and/or anchoring. The best-studied MTOC is the centrosome, a non-membrane bound organelle composed of two centrioles surrounded by pericentriolar material (PCM).
which of these statements accurately describes an mtoc?
which of these statements accurately describes an mtoc?

What is MTOC biology?

Known as the main microtubule organizing center of animal cells (MTOCs), the centrosome participates in the organization of the microtubule network within the cell. It is formed of two centrioles surrounded by a structured matrix of proteins called the pericentriolar material (PCM).

What serves as the MTOC for cilia?

In animals, the MTOCs serve two roles. MTOCs associated with cilia are referred to as basal bodies. Those associated with the formation of the spindle apparatus are called centrosomes. A basal body is a structure found at the base of eukaryotic cilia and flagella.

Is basal body an MTOC?

The basal body serves as a nucleation site for the growth of the axoneme microtubules. Centrioles, from which basal bodies are derived, act as anchoring sites for proteins that in turn anchor microtubules, and are known as the microtubule organizing center (MTOC).
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