does a fetus have different dna than the mother

does a fetus have different dna than the mother

does a fetus have different dna than the mother

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Unborn babies are unique beings, nourished by mother

It says it is not a baby until it is born (“logically separated”). So that begs the question: What is birth? Is it only when the birth is spontaneous that it is a baby? If that is the case, the mother can abort the baby at any time in the pregnancy right up until full term.

Few Americans agree with that except the Democratic Party leadership. Medical advances have improved the viability of premature babies. Babies as early as 22 weeks of gestation have survived. The fetal heartbeat bill will allow medical advances of viability to continue.

Why is killing a fetus legal if the mother doesn’t want it, but considered murder by the courts if she does want it? Which is it, a fetus or a baby?

The unborn baby is a unique individual nourished by its mother. It has its own DNA. It is not an extension of the mother.

does a fetus have different dna than the mother
does a fetus have different dna than the mother


Fetal DNA Sequenced From Mother’s Blood

A baby might have its mother’s eyes, but the mother has the child’s DNA in her blood, at least during pregnancy. Researchers have now used this

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DNA to test for a genetic disease before birth. The technique might allow doctors to perform prenatal screening from only a sample of the mother’s blood.

Prenatal diagnosis to check for chromosome abnormalities and genetic diseases is common. Doctors capture fetal cells for DNA analysis using amniocentesis,

which taps some of the fluid in the womb, or chorionic villus sampling, which plucks a snippet of tissue from the placenta. Although safe, both tests slightly

raise the chances of a miscarriage, spurring researchers to look for alternatives. In 1997, chemical pathologist Y. M. Dennis Lo, now at the Chinese University of Hong Kong,

and colleagues discovered a rich vein of fetal DNA in, well, the mother’s veins.

About 10% of the DNA fragments floating in the mother’s blood comes from the fetus, from dying placental or fetal cells. Clinical tests capitalize on

this DNA to discern the baby’s sex and determine whether mother and child have incompatible Rh blood groups, which can lead to fatal complications.

But the difficulty of distinguishing maternal DNA from fetal DNA has prevented researchers from developing tests to test for most other genetic conditions.

does a fetus have different dna than the mother
does a fetus have different dna than the mother

To overcome this problem, Lo and colleagues applied cutting-edge DNA-sequencing techniques, which can rapidly sequence large amounts of DNA,

to the billions of DNA fragments in a blood sample from a pregnant woman. Using DNA samples from a woman and her husband, the team analyzed

approximately 900,000 single-nucleotide polymorphisms, one-letter changes in the genetic code that reveal where the DNA of the parents differs.

With this information, the researchers first determined that the mother’s blood carries all of the fetus’s genome and which DNA the baby inherited from each parent.

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The team then tested the approach on a pregnant women at an obstetric clinic. The woman and her partner each carried a faulty copy of the gene

for one part of hemoglobin, which predisposed her fetus to ß-thalassemia, which can lead to severe anemia. The team’s tests showed that the baby

didn’t have ß-thalassemia but was a carrier, receiving a mutated version of the gene from the father and a normal one from the mother. Analysis

of the baby’s DNA obtained by chorionic villus sampling, which the mother had also undergone, confirmed the diagnosis. “We have worked out

the principle and achieved the first noninvasive genetic scan of a fetus from the mother’s blood,” says Lo, whose team reports its findings online today in Science Translational Medicine.

does a fetus have different dna than the mother
does a fetus have different dna than the mother

Several obstacles stand in the way of widespread use of fetal DNA analysis, however. For one, the type of DNA sequencing used in the study is too expensive

for clinical testing, although most researchers expect its cost to plummet in the next few years. The results are also very complex and hard to interpret,

notes reproductive geneticist Diana Bianchi of Tufts University School of Medicine in Boston. “It’s a brilliant proof-of-principle study, but it’s not ready for clinical application.”

Still, many researchers are impressed. “I think it’s a beautiful piece of work,” says molecular geneticist Arthur Beaudet of Baylor College of Medicine

in Houston, Texas. “It’s an important step in the direction of showing the capability of this approach,” adds Mark Evans, an obstetrician- gynecologist

and geneticist at the Mount Sinai School of Medicine in New York City. Molecular biologist Sinuhe Hahn of University Women’s Hospital in Basel,

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Switzerland, says that the approach should allow fetal DNA testing for a variety of other genetic diseases, such as cystic fibrosis and Tay-Sachs disease.

“In essence, you have the entire genome of the fetus at your disposal.”



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